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No other brand name or logo mentioned on this website is affiliated with Xcode Life. The COMT gene is an essential gene when it comes to determining the development of our personalities, identities, and dispositions. This gene codes for the catechol-o-methyltransferase enzyme that inactivates or breakdown catechols, which are a type of neurotransmitters in the brain, like dopamine. These neurotransmitters are responsible for brain functions like short-term memory, planning, and cognitive abilities.
There are two types of COMT genes :. It has more affinity for dopamine and therefore, plays a more significant role in inactivating dopamine in the brain. It has a lesser affinity for dopamine and is located in peripheral tissues like liver, blood, etc.
When a small piece of chromosome 22 gets deleted as part of the 22q Due to this deletion, people with this disorder have only one copy of the gene instead of two. Loss of one copy of the COMT gene results in abnormal regulation of the COMT enzyme in the brain and increases the risk of developing behavioral problems and mental illnesses. Catecholamines like norepinephrine, epinephrine, and dopamine lower the threshold for an aggressive response to external stimuli.
MAO is located on the outer membrane of the mitochondriai.Of 1917 1080p
As mentioned above, COMT is also of two types, where one is membrane-bound, and the other is soluble. MAO enzyme is responsible for deactivating primary, secondary and tertiary amines that are found in the brain, liver, and kidney.
They play an important role in metabolizing the biogenic amines and oxidizing xenobiotics like aniline. MAO is responsible for deactivating amines like dopamine, which is a chemical messenger in the brain.
In such cases, treatment with a dopamine drug is not useful as it cannot cross the brain barrier. So, MAO inhibitors are used that prevent the breakdown of dopamine and make it available for use in the brain. These drugs are prescribed for patients to block the action of the MOA enzyme and prevent the breakdown of dopamine.
COMT vm is the most studied SNP of the gene because it plays a vital role in intelligence, personality and the risk of developing a disease.
So, if you have AA, then you will have the highest amount of dopamine and GG would mean the lowest amount of it.This means that these neurotransmitters prevent major depression and can increase our mood, especially dopamine and serotonin.
People with low MAO-A are more likely to be risk takers. There are only SNPs that correlate with these versions somewhat. It depends on groups of SNPs and also on your gender. On the other hand, men but not females with the T allele had higher rates of suicide compared to controls The 2R version and the 3.Google drive disappeared from finder
Rs — Males with rs Crs G and rs A had higher scores on the scale measuring the expression of anger outwards. These are just some suggestions and are not to be taken as medical advice, but I highly recommend seeing a functional doctor who is knowledgeable in gene testing as well as getting your hormone levels tested, this will help you to better pinpoint what hormone you need to target with supplementation!P30l in stock
Thanks for the encouragement! Did your son have the T allele? Did you treat him with the progesterone? If so, what dose and brand? Your email address will not be published. Yes, add me to your mailing list. Leave a Reply Cancel reply Your email address will not be published.Xcode Life is an independent entity. No other brand name or logo mentioned on this website is affiliated with Xcode Life. Search by Gene name, Trait name or Report type.
These enzymes are part of a larger family of enzymes that break down monoamine molecules through oxidation. They are also majorly involved in the breakdown of neurotransmitters like dopamine and serotonin. Thus, mutations in the MAO-A gene can directly affect the levels of these neurotransmitters, which can potentially lead to various behavior-associated disorders.
This results in monoamine oxidase A deficiency, which reportedly follows an X-Linked inheritance pattern. Various studies have linked this build-up with unusual behavioral patterns involving aggressive outbursts and abnormal sexual behavior. The deficiency of this enzyme has also been associated with abnormal development of the brain which can directly lead to intellectual disabilities. There are many variants of the MAO-A gene that directly results in lower or higher levels of the enzyme in our body.
Higher levels of the enzyme result in lower levels of neurotransmitters like serotonin and dopamine in the brain. Lower levels of the enzymes lead to the build-up of neurotransmitters which results in a higher risk of aggressive and impulsive behavior.
Several studies have established a strong connection between lower enzymatic activity and aggressive behavior. Thus, if you possess the genetic variant that results in lower levels of the enzyme, there is a higher tendency for you to develop aggression.
However, it is important to note that the influence this gene has on aggression is also moderated by environmental factors. A study reported that in high-stress or violent environments, people carrying the lower expression variant of the gene displayed predictable aggressive reactions, but in calmer settings, they were in control of their impulses. Ultimately, when it comes to behavioral traits, both genetics and the environment have an equal say. This delves into the topic of behavioral genetics, which is a controversial topic in and of itself.
Posts Latest Activity. Page of 2. Filtered by:. Previous 1 2 template Next. Warrior Gene 16th JulyPM. This issue is being discussed in other threads. Tags: None. Originally posted by Yaffa View Post.
MAOA” The Warrior Gene”
Comment Post Cancel.In sports, business or your personal life, how you respond to stress and aggression may be in your genes, or at least partly so. Human behavior is complex and influenced by our genes, our environment, and our circumstances.
With bullying and violent crime making headlines, this controversial finding stirs up the nature-versus-nurture debate. Who has the warrior gene? And are all violent people carriers? The results turn assumptions upside down.
Here Is Everything You Need To Know About MAO-A: The Warrior Gene
A rock band front man. A bullet-scarred Harley rider. A former gang member from East L. Even a Buddhist monk with a far-from-peaceful past. Which one carries the gene associated with violence? Many experts believe our upbringing and environment are the primary influences on our behavior, but how much are we predisposed by our DNA? The discovery of a single gene variation affecting only men, which appears to play a crucial role in managing anger, argues that nature may have a far bigger influence on behavior.
Some of his tattoos are too provocative and socially offensive to show. In this special Explorer episode, he dives into his own history of rage and searches out others with aggressive behavior from a range of different backgrounds. Follow Rollins as he meets with former foot soldiers in one of the most violent street gangs in East Los Angeles; fighters in the ultraviolent sport of mixed martial arts, and Harley Davidson bikers.
After learning more about the warrior gene, many of the men believe they have it, which could offer an explanation of their past behavior.
Then, Explorer takes a look at the original study — on one family with generations of men displaying patterns of extreme physical aggression — that led Dutch geneticist Dr. Han Brunner to the revolutionary discovery of this rare genetic dysfunction. In one study attempting to demonstrate this, subjects are given permission to administer punishment to their partner who was secretly instructed to make a nuisance of himselfwith unexpected results.
So wanna know who, in the documentary, had the warrior gene? Well, hint…. The link to watch the video is below. The Warrior Gene is a variant of the gene MAO-A on the X chromosome and is one of many genes that play a part in our behavioral responses. Because men have one copy of the X-chromosome, a variant that reduces the function of this gene has more of an influence on them. Women, having two X-chromosomes, are more likely to have at least one normally functioning gene copy, and scientists have not studied variants in women as extensively.
Recent studies have linked the Warrior Gene to increased risk-taking and aggressive behavior. Whether in sports, business, or other activities, scientists found that individuals with the Warrior Gene variant were more likely to be combative than those with the normal MAO-A gene.
However, human behavior is complex and influenced by many factors, including genetics and our environment. Individuals with the Warrior Gene are not necessarily more aggressive, but according to scientific studies, are more likely to be aggressive than those without the Warrior Gene variant. This test is available for both men and women, however, there is limited research about the Warrior Gene variant amongst females.
You also acknowledge that this forum may be hosted outside your country and you consent to the collection, storage, and processing of your data in the country where this forum is hosted. I Agree. Logging in Remember me. Log in. Forgot password or user name? Warrior gene? Posts Latest Activity. Page of 2. Filtered by:. Previous 1 2 template Next. Tags: None. I wonder what they mean by "violent".
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The url name "warrior gene" is somewhat misleading. The webpage talks about violence. To me there is a subtle difference between "warrior" and "violent".
Personalized Nutrition – Powered by Your DNA
I'd rather be around a "warrior" than be around a violent person. A "warrior" can be thougtful and control and steady himself and have a noble purpose construction, carpentry, activists and so on. And the average guy that is into sports. Maybe the "God gene" makes the difference. I do believe some people are born violent the criminally insanebut it is rare, much rarer than the 1 in 3 the url says.
But human history is very violent. Look at all the wars that happened all around the globe for thousands of years. I read that there is archaeological evidence that humans killed genocide the Neanderthals. I think most of the violent people men killed each other off and that is why we eventually became a mostly-docile people and were able to create art and architecture and music and civilizations.
Last edited by rainbow ; 6th DecemberAM. The Vikings were notoriously violent. Nowadays Scandinavia has the most placid, milktoast, mild population that I know of. Their police don't even have guns.Posted on January 8, by Debbie Moon. Leave a Comment. Having trouble with supplements containing methyl groups? Wondering why your neurotransmitters are out of balance? It could be due to your COMT genetic variants.
This important enzyme is tasked with breaking down neurotransmitters, such as dopamine. To do this, the enzyme adds a methyl group from SAMe to the dopamine, epinephrine, or norepinephrine molecules, thus changing them into a different substance so that the body can then get rid of it.
There are several common genetic variants that alter how the enzyme functions. Researchers link COMT genetic variants to quite a variety of different diseases from mood disorders to heart disease, possibly due to the COMT variants metabolizing neurotransmitters at different rates.
Some of the psychiatric disorders with increased risk associated with COMT variants include schizophrenia[ ref ][ ref ], depression [ ref ], anxiety, and bipolar disorder.Warrior Gene! Gedmatch, FTDNA, myfreeviewgiveself.pw, 23&me, and Promethease discussion.
Outside of the brain, COMT also breaks down estrogens. Estrogens can inhibit COMT, leading to an increase in dopamine in female brains. This variant affects the rate at which the enzyme function.
There is a lot written on the internet about COMT — from Facebook groups to clinicians making videos on the topic. So instead of one allele being bad and one being goodstudies show these common variants just add to our uniqueness. Instead of focusing on bad vs good, I suggest looking at the various interactions between your genotype and supplements or lifestyle factors.
Use the genetic information to optimize your health — mental and physical. Not a member? Find out more. Check your genetic data for rs 23andMe v. This common variant also changes the activity level of COMT. The T allele is the less common version, with lower COMT enzyme activity; C is the more common version with higher activity.7mm rifle range
This includes quercetin, EGCG, and luteolin [ ref ][ ref ]. If you have lower COMT enzyme activity, you may want to be careful of stacking too many supplements together at the same time that are metabolized using the COMT enzyme. A study in mice found that COMT deficiency led to glucose intolerance on a high-fat diet. Test your blood glucose levels and keep track of whether dietary fat impacts your levels.
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